Clinically studied picks
Moisturizers with research you can read.
No single brand has been proven better than the rest. The best moisturizer is the one you'll actually use. These have the most product-specific evidence on our working list.
Affiliate disclosure: Studied Things may earn a commission if you buy through links on this page, at no extra cost to you. Commissions never decide what we list or how we rate it. Right now no affiliate programs are approved, so every link below is a plain, unpaid link.
Tier 1 · Clinically studiedOatmeal moisturizerAveeno Eczema Therapy Daily Moisturizing Cream
A steroid-free daily cream with 1% colloidal oatmeal, an FDA-recognized skin protectant.
Evidence: Double-blind RCT, 90 children: a 1% colloidal oatmeal cream was non-inferior to a prescription barrier cream over 3 weeks.
Lisante 2017 ↗Funded by the maker (J&J, now Kenvue). Heads-up: Rare oat sensitivity. Confirm the current formula matches the studied one.
Tier 1 · Clinically studiedOatmeal lotionCetaphil Restoraderm Eczema Soothing Moisturizer
A lighter lotion with 1% colloidal oatmeal and ceramide NP, for itchy, eczema-prone skin.
Evidence: Randomized, blinded split-body study, 33 people: itch dropped sharply within 24 hours after one application.
Nguyen 2026 ↗Small, short study; authors include maker (Galderma) staff. Heads-up: Contains sunflower and shea (rare sensitivities).
Tier 1 · Clinically studiedOintment · handsAquaphor Healing Ointment
A petrolatum ointment for cracked, chapped hands and night-time sealing.
Evidence: Split-hand, evaluator-blinded RCT, 26 adults with chronic hand eczema: hand eczema scores and barrier measures improved over 28 days.
Lueangarun 2025 ↗No funding or conflicts declared. Heads-up: Contains lanolin alcohol, a known contact allergen. No NEA Seal. Greasy.
Working list: we're still checking exact formulas and who funded the studies, and we'll update this page as we finish. More picks, including Tier 2 options, are on the gear page.